Development of decellularized scaffolds for stem cell-driven tissue engineering.
Identifieur interne : 000E36 ( Main/Exploration ); précédent : 000E35; suivant : 000E37Development of decellularized scaffolds for stem cell-driven tissue engineering.
Auteurs : Deepti Rana [Inde] ; Hala Zreiqat [Australie] ; Nadia Benkirane-Jessel [France] ; Seeram Ramakrishna [Singapour] ; Murugan Ramalingam [Inde]Source :
- Journal of tissue engineering and regenerative medicine [ 1932-7005 ] ; 2017.
Abstract
Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions. However, a dearth of available donor organs for transplantation leads to the death of numerous patients waiting for a suitable organ donor. The potential of decellularized scaffolds, derived from native tissues or organs in the form of scaffolds has been evolved as a promising approach in tissue-regenerative medicine for translating functional organ replacements. In recent years, donor organs, such as heart, liver, lung and kidneys, have been reported to provide acellular extracellular matrix (ECM)-based scaffolds through the process called 'decellularization' and proved to show the potential of recellularization with selected cell populations, particularly with stem cells. In fact, decellularized stem cell matrix (DSCM) has also emerged as a potent biological scaffold for controlling stem cell fate and function during tissue organization. Despite the proven potential of decellularized scaffolds in tissue engineering, the molecular mechanism responsible for stem cell interactions with decellularized scaffolds is still unclear. Stem cells interact with, and respond to, various signals/cues emanating from their ECM. The ability to harness the regenerative potential of stem cells via decellularized ECM-based scaffolds has promising implications for tissue-regenerative medicine. Keeping these points in view, this article reviews the current status of decellularized scaffolds for stem cells, with particular focus on: (a) concept and various methods of decellularization; (b) interaction of stem cells with decellularized scaffolds; (c) current recellularization strategies, with associated challenges; and (iv) applications of the decellularized scaffolds in stem cell-driven tissue engineering and regenerative medicine. Copyright © 2015 John Wiley & Sons, Ltd.
DOI: 10.1002/term.2061
PubMed: 26119160
Affiliations:
- Australie, France, Inde, Singapour
- Alsace (région administrative), Grand Est, Nouvelle-Galles du Sud
- Strasbourg, Sydney
- Université de Sydney, Université nationale de Singapour
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Copyright © 2015 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Inde</li><li>Singapour</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Strasbourg</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Inde"><noRegion><name sortKey="Rana, Deepti" sort="Rana, Deepti" uniqKey="Rana D" first="Deepti" last="Rana">Deepti Rana</name></noRegion><name sortKey="Ramalingam, Murugan" sort="Ramalingam, Murugan" uniqKey="Ramalingam M" first="Murugan" last="Ramalingam">Murugan Ramalingam</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Zreiqat, Hala" sort="Zreiqat, Hala" uniqKey="Zreiqat H" first="Hala" last="Zreiqat">Hala Zreiqat</name></region></country><country name="France"><region name="Grand Est"><name sortKey="Benkirane Jessel, Nadia" sort="Benkirane Jessel, Nadia" uniqKey="Benkirane Jessel N" first="Nadia" last="Benkirane-Jessel">Nadia Benkirane-Jessel</name></region></country><country name="Singapour"><noRegion><name sortKey="Ramakrishna, Seeram" sort="Ramakrishna, Seeram" uniqKey="Ramakrishna S" first="Seeram" last="Ramakrishna">Seeram Ramakrishna</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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